2 edition of effects on diazepam on the critical flicker frequency (CFF) of pigtail monkeys (Macaca nemestrina) found in the catalog.
effects on diazepam on the critical flicker frequency (CFF) of pigtail monkeys (Macaca nemestrina)
Walter Philip Weisenburger
Written in English
|Statement||by Walter Philip Weisenburger.|
|The Physical Object|
|Pagination||ix, 43 leaves, bound :|
|Number of Pages||43|
The investigation was designed to examine the question of whether anxiety-related cognitive bias is reduced by diazepam in subjects selected according to DSM-III(R) criteria for generalized anxiety disorder (American Psychiatric Association, ). Electroencephalographic activity in the high-frequency range (>20 Hz) is prominent during sensory processing and cognition. It is a signature of conscious cognitive functions and subject to modulation by clinically used benzodiazepines, which act by positive allosteric modulation of GABA A receptors. Diazepam is a prototypical benzodiazepine that targets a family of GABA A receptor subtypes.
In humans the critical flicker fusion (CFF) threshold, or the frequency at which a light appears to be completely steady to the observer, can be as low as 24Hz or 24 "flickers" per second. andatory. Critical flicker frequency (CFF) is a simple diagnostic test. Aim The aim of this study was to assess the diagnostic accuracy of CFF test for MHE. Patients and methods A total of 86 patients with cirrhosis with negative history of overt hepatic encephalopathy were included. History, clinical examination, laboratory investigations, and abdominal ultrasonography data were collected.
Using the critical flicker fusion frequency test (CFF) significant decrements in performance were found after diazepam monotherapy only. 5. In summary, there was no evidence that either nimodipine or diazepam affected the pharmacokinetics, safety and tolerance of each other. Critical flicker frequency series effect. Budapest, Akadémiai Kiadó, (OCoLC) Online version: Ákos, Károly. Critical flicker frequency series effect. Budapest, Akadémiai Kiadó, (OCoLC) Document Type: Book: All Authors / Contributors: Károly Ákos; Magda Ákos.
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Brit. Anaesth. (), 43, CRITICAL FLICKER FREQUENCY AFTER SMALL DOSES OF METHOHEXITONE, DIAZEPAM AND SODIUM 4-HYDROXYBUTYRATE BY I. GROVE-WHITE AND G.
KELMAN SUMMARY Statistically significant depression of critical nicker frequency has been measured following the intravenous injection of methohexitone ( mg/kg), diazepam Cited by: The effects of oral oxprenolol ( mg) or propranolol ( or mg) and of diazepam (5 mg) or lorazepam (2 mg) on pursuit rotor performance, reaction time and critical flicker frequency were investigated in healthy subjects in 3 separate by: The effects of 10 mg diazepam on signal detection theory measures (stimulus sensitivity, response bias) and reaction times were studied in a 1-hour visual signal detection task with high and low signal probability, and on performance in two short-duration tasks: Critical Flicker-Fusion Frequency (CFF) and the Digit Symbol Substitution Test Cited by: The effect of diazepam (10 mg, p.o.) on the responsiveness of eccrine sweat glands to intradermally injected carbachol and on critical flicker fusion frequency was compared in 6 male healthy volunteers under two ambient temperature conditions, 22 °C and 35 °C.
Carbachol evoked dose-related increases in sweat gland activity. Responsiveness to carbachol was significantly enhanced under the Cited by: 6. Abstract Effects on critical flicker fusion frequency (CFFF), coordination and mood were studied after single oral doses of placebo, alcohol ( ml ethanol/kg b.
wt.), oxazepam (10, 20 and 40 mg), diazepam (5, 10, 20 and 40 mg) and methylperone (10, 25 and 50 mg), given either alone, or simultaneously with alcohol or with delayed alcohol by: Evaluation of signal detection theory on the effects of psychotropic drugs on critical flicker-fusion frequency in normal subjects.
MacNab MW, Foltz EL, Sweitzer J. Critical flicker-fusion frequency (CFF) has often been applied to psychotropic drug evaluation as a measure of cortical arousal. affected by therapeutic levels of diazepam. Critical flicker fusion frequency seemed to be sensitive to diazepam, and in the literature the reduction in fusion frequency was general.
Various performances involv-ing decision-making effects on diazepam on the critical flicker frequency book indications of a dose-related response; two studies using diazepam 10 mg showednoeffect, whereas twostudies.
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Data sources include IBM Watson Micromedex (updated 10 Aug ), Cerner Multum™ (updated 3 Aug ). After the intake of 5 mg Diazepam (Valium), eight male subjects showed a marked decrease in CFF and a significant shift of subjective reports of tiredness.
In a field study of 68 air traffic controllers, the CFF showed a significant correlation with subjective reports of fatigue and it decreased more for night-shift than for day-shift personnel. Judged by clinical examination diazepam had a less marked effect on proprioception, speech and balance than ethanol.
The effect of diazepam on the Flicker Fusion and Mirror Tracing tests could still be recognized 4 1 / 2 hr after administration of the drug. The effect of diazepam (10 mg, p.o.) on the responsiveness of eccrine sweat glands to intradermally injected carbachol and on critical flicker fusion frequency was compared in 6 male healthy volunteers under two ambient temperature conditions, 22 degrees C and 35 degrees C.
Carbachol evoked dose-related increases in sweat gland by: 6. We have studied the effect of i.v. flumazenil mg kg −1 on the amnesia and sedation caused by midazolam 2 mg and 5 mg i.v.
in volunteers in order to determine the relationship between the actions of the antagonist on these two effects. Midazolam caused dose-dependent central neural depression as assessed by critical flicker fusion frequency, and dose-dependent amnesia for word. In Meyler's Side Effects of Drugs (Sixteenth Edition), Light meals.
The effects of a light meal on the pharmacokinetics and pharmacodynamics of three benzodiazepines have been investigated in 21 subjects who were randomized to quazepam 20 mg, diazepam 5 mg, or nitrazepam 5 mg .Each took a single oral dose of the assigned drug after an overnight fast and on a separate occasion after a.
Smith JM, Misiak H. Critical flicker frequency (CFF) and psychotropic drugs in normal human subjects-a review. Psychopharmacologia. May 28; 47 (2)– [Google Scholar] Stitt FW, Latour R, Frane JW.
A clinical study of naproxen-diazepam drug interaction on tests of mood and attention. Curr Ther Res Clin Exp. Feb; 21 (2)– Diazepam is a benzodiazepine (ben-zoe-dye-AZE-eh-peens). It is thought that diazepam works by enhancing the activity of certain neurotransmitters in the brain.
Diazepam is used to treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam is sometimes used with other medications to treat seizures.
Important Information. Abstract. The infuluence of dizepam and nitrazepam on arousal level, muscle strength, psychomotor performance and memory function using the photopalpebral reflex (PPR), critical flicker frequency (CFF), tapping test, (CRT) and mamory drum test (MDT) were investigated in the present study.
Doxepin (Quitaxon®) at doses of 25, 50, and 75 mg was compared with diazepam15, and mg, using as variables the percentage lowering of Critical Flicker Fusion (CFF) and the self-estimated degree of drowsiness.
Single doses were given, and repeated effect determinations were made over 6 h. Clear dose-effect relations could be demonstrated. The two drugs differed in speed and duration. Critical flicker-fusion frequency (CFF) is the maximum frequency of flicker that is discriminable from a steady light.
Reduction in CFF is a valuable and commonly employed measure of the effects of BZDs and other sedatives (Smith and Misiak,Hindmarch, ). Critical flicker Doses of diazepam. fusion frequency decreased significantly up to 4 and 6 hr after mg/kg and mg/kg of diazepam respectively as compared with the preinjection values.
The ability to discriminate a flickering light after mg/kg of diazepam was similar to that after mg/kg and significantly worse at 4, 6 and 8 hr. Walter Philip Weisenburger has written: 'The effects on diazepam on the critical flicker frequency (CFF) of pigtail monkeys (Macaca nemestrina)' -- subject(s): Physiological effect, Diazepam.
This literature review presents summary methodological and statistical data on 33 studies in which critical flicker frequency (CFF) thresholds were used to evaluate the effects of acute oral doses of single psychotropic drugs in normal human subjects.
In all, 96 drug-dose-study combinations are represented. CFF was found to be altered to a statistically significant degree (P.The comparative hypnotic effects of secobarbital, methaqualone and placebo in normal subjects and in psychiatric patients.
J Pharmacol Exp Ther. May; (2)– Grove-White IG, Kelman GR. Critical flicker frequency after small doses of methohexitone, diazepam and sodium 4-hydroxybutyrate. Br J Anaesth.
Feb; 43 (2)–DIAZEPAM (‘Valium’, Roche) is a recently introduced anti-anxiety drug of the 1,4-benzodiazepine series1,2. Clinically, it is usually said to act for 6–8 h, but quantitative data about the.